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Research Article

Novel Hematologic Markers for Risk Stratification in Bladder Cancer Patients Receiving BCG Treatment


1 Department of Urology, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Istanbul,
Türkiye
2 Department of Urology, University of Bahçeşehir, Medical Park Göztepe Hospital, Istanbul, Türkiye


DOI : 10.33719/nju1694756
New J Urol. 2025;20(2):104-112.

Abstract

Squamous cell papilloma of the bladder is an exceedingly rare benign lesion. It is often identified incidentally during imaging studies performed for unrelated reasons and may mimic urothelial carcinoma of the bladder. The definitive diagnosis of this lesion, which can present with varying clinical symptoms, is established through pathological examination. Here, we report a case of squamous cell papilloma in a 56-year-old asymptomatic male patient. The patient underwent cystoscopy after a suspicious lesion was observed on full-abdominal CT imaging, raising concern for a bladder tumor. During cystoscopy, transurethral resection was performed on calcified exophytic lesions observed in the bladder, achieving complete resection of all lesions. Histopathological analysis revealed the lesion to be a squamous cell papilloma, and the patient was placed under follow-up. The etiology and clinical significance of these lesions, which are rarely reported in the literature, remain unclear. In this article, we summarize the case of squamous cell papilloma of the bladder while reviewing the relevant literature. We believe that this report contributes to the literature by emphasizing the importance of accurate pathological evaluation for urologists and preventing overly aggressive treatments for patients. 


Abstract

Squamous cell papilloma of the bladder is an exceedingly rare benign lesion. It is often identified incidentally during imaging studies performed for unrelated reasons and may mimic urothelial carcinoma of the bladder. The definitive diagnosis of this lesion, which can present with varying clinical symptoms, is established through pathological examination. Here, we report a case of squamous cell papilloma in a 56-year-old asymptomatic male patient. The patient underwent cystoscopy after a suspicious lesion was observed on full-abdominal CT imaging, raising concern for a bladder tumor. During cystoscopy, transurethral resection was performed on calcified exophytic lesions observed in the bladder, achieving complete resection of all lesions. Histopathological analysis revealed the lesion to be a squamous cell papilloma, and the patient was placed under follow-up. The etiology and clinical significance of these lesions, which are rarely reported in the literature, remain unclear. In this article, we summarize the case of squamous cell papilloma of the bladder while reviewing the relevant literature. We believe that this report contributes to the literature by emphasizing the importance of accurate pathological evaluation for urologists and preventing overly aggressive treatments for patients.